2022
Cao Y, Vergnes L, Wang YC, Pan C, Krishnan K, Moore T, Rosa-Garrido M, Kimball T, Zhou Z, Charugundla S, Rau CD, Seldin M, Wang J, Wang Y, Vondriska T, Reue K, Lusis AJ. Sex Differences in Heart Mitochondria Regulate Diastolic Dysfunction. Nature Communications. in press (2022)
Pillai ICL, Xu S, Rau CD, Wang Z. Epigenetic Regulation in Cardiovascular Diseases. Front Cardiovasc Med 8:831851. doi:10.3389/fcvm.2021.831851 (2022)
2021
Wang L, Wada Y, Ballan N, Schmeckpeper J, Huang J, Rau CD, Wang Y, Gepstein L, Knollmann BC. Triiodothyronine and dexamethasone alter potassium channel expression and promote electrophysiological maturation of human-induced pluripotent stem cell-derived cardiomyocytes. J Mol Cell Cardiol. 161:130-138 doi: 10.1016/j/yjmcc.2021.08.005 (2021)
Baranowski BJ, Allen MD, Nyarko JN, Rector RS, Padilla J, Mousseau DD, Rau CD, Wang Y, Laughlin MH, Emter CA, MacPherson RE, Olver TD. Cerebrovascular Insufficiency and Amyloidogenic Signaling in Ossabaw Swine with Cardiometabolic Heart Failure. JCI Insight 6(10); doi:10.1172/jci.insight.143141 (2021)
Kelly SC, Rau CD, Ouyang A, Thorne PK, Olver TD, Edwards JC, Domeir TL, Padilla J, Grisanti LA, Fleenor BS, Wang Y, Scott R, Emter CA. The Right Ventricular Transcriptome Signature in Ossabaw Swine with Cardiometabolic Heart Failure: Implications for the Coronary Vasculature. Physiol Genomics 53(3):99-115; doi: 10.1152/physiolgenomics.00093.2020 (2021)
2020
Rau CD, Gonzales NM, Bloom JS, Park D, Ayroles J, Palmer AA, Lusis AJ, Zaitlen N. Modeling Epistasis in Mice and Yeast Using the Proportion of Two or More Distinct Genetic Backgrouds: Evidence for “Polygenic Epistasis”. PLoS Genet 16(10): e1009165; doi: 10.1371/journal.pgen1009165 (2020)
Krebber MM, van Dijk CGM, Vernooij RWM, Brandt MM, Emter CA, Rau CD, Fledderus JO, Dunker DJ, Verhaar MC, Cheng C, Joles JA. Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases in Extracellular Matrix Remodeling During Left VEntricular Diastolic Dysfunction and Heart Failure with Preserved Ejection Fraction: A Systemic Review and Meta-Analysis. Int J Mol Sci Sept 14;21(18) (2020)
Yokota T, Li J, Huang J, iong Z, Zhang Q, Chan TW, Ding Y, Rau CD, Sung K, Ren S, Kulkarni RP, Hsiai T, Xiao X, Touma M, Minamisawa S, Wang Y. p38 Mitogen-activated Protein Kinase Regulates Chamber Specific Perinatal Growth in Heart. J Clinical Investigation 2020 June 23 (2020)
Rau CD, Lusis AJ, Wang Y. Systems Genetics for Mechanistic Discovery in Heart Diseases. Circulation Research 2020 Jun 5; 126(12):1795-1815 (2020)
2019
Olver TD, Edwards JC, Jurrissen TJ, Veteto AB, Jones JL, Gao C, Rau C, Warren CM, Klutho PJ, Alex L, Ferreira-Nichols SC, Ivey JR, Thorne PK, McDonald KS, Krenz M, Baines CP, Solaro J, Wang Y, Ford DA, Domeier TL, Padilla J, RecFtor RS, Emter CA. Western Diet-fed, Aortic-Banded Ossabaw Swine: A Pre-Clinical Model of Cardio-Metabolic Heart Failure. JACC Basic Translational Science 4(3):404-421 (2019)
Tzimas C, Rau CD, Buergisser PE, Jean-Louis G, Lee K, Chukwuneke J, Dun W, Wang Y, Tsai EJ. Wipi1 is a Conserved Mediator of Right Ventricular Failure. JCI Insight. 2019 Apr 25;5. pii: 122929 (2019).
2018
Lin L, Chun-Chang S, O’Hearn J, Hui ST, Seldin M, Gupta P, Bondar G, Deng M, Jauhiainen R, Kuusisto J, Laakso M, Sinsheimer JS, Deb A, Rau C, Ren S, Wang Y, Lusis AJ, Wang JJ, Huertas-Vazquez A. Systems Genetics Approach to Biomarker Discovery: GPNMB and Heart Failure. G3 pii: g3.200655.2018 (2018)
Park S, Ranjbarvaziri S, Lay FD, Zhao P, Miller MJ, Dhaliwal JS, Huertas-Vasquez A, Wu X, Qiao R, Soffer JM, Rau C, Wang Y, Mikkola HKA, Lusis AJ, Ardehali R. Genetic Regulation of Fibroblast Activation and Proliferation in Cardiac Fibrosis. Circulation 18:1224-1235 (2018)
Santolini M, Romay MC, Yukhtman CL, Rau CD, Ren S, Saucerman JJ, Wang JJ, Weiss JN, Wang Y, Lusis AJ, Karma A. A Personalized, Multiomics Approach Identifies Genes Involved in Cardiac Hypertrophy and Heart Failure. NPJ Systems Biology and Applications 4:12 (2018)
Chang SC, Ren S, Rau CD, Wang JJ. Isoproterenol-Induced Heart Failure Mouse Model Using Osmotic Pump Implantation. Methods in Molecular Biology 1816:207-220 (2018)
2017
Rau CD, Vonriska TM. DNA Methylation and Human Heart Failure: Mechanisms or Prognostics. Circulation 136(16):1545-1547 (2017)
Patterson M, Barske L, Van Handel B, Rau CD, Gan P, Sharma A, Parikh S, Denholtz M, Huang Y, Yamaguchi Y, Shen H, Allayee H, Crump JG, Force TI, Lien CL, Makita T, Lusis AJ, Kumar SR, Sucov HM. Frequency of Mononuclear Diploid Cardiomyocytes Underlies Natural Variation in Heart Regeneration. Nature Genetics 49(9):1346-1353 (2017)
Wisniewski N, Bondar G, Rau C, Chittoor J, Chang E, Esmaeili A, Cadeiras M, Deng M. Integrative Model of Leukocyte Genomics and Organ Dysfunction in Heart Failure Patients Requiring Mechanical Circulatory Support: a Prospective Observational Study. BMC Med Genomics 10(1):52 (2017)
Rau CD, Romay MC, Tuteryan M, Wang JJ, Santolini M, Ren S, Karma A, Weiss JN, Wang Y, Lusis AJ. Systems Genetics Approach Identifies Gene Pathways and Adamts2 as Drivers of Isoproterenol-Induced Cardiac Hypertrophy and Cardiomyopathy in Mice. Cell Systems 4(1):121-128 (2017)
Gao C, Howard-Quijano K, Rau CD, Takamiya T, Song Y, Shivkumar K, Wang Y, Mahajan A. Inflammatory and Apoptotic Remodeling in Autonomic Nervous System Following Myocardial Infarction. PloS one. 12(5):e0177750 (2017)
Seldin MM, Kim ED, Romay MC, Li S, Rau CD, Wang JJ, Wang Y, Deb A, Lusis AJ. Systems genetics approach identifies Trp53inp2 as a link between cardiomyocyte glucose utilization and hypertrophic response. Am J Physiol Heart Circ Physiol. doi:10.1152/ajpheart.00068.2016 (2017)
Rau CD, Civelek M, Pan C, Lusis AJ. Algorithms for the visualization and integration of systems genetics data. Methods in Molecular Biology. 1488,153-188 (2017)
2016
Rau CD, Gao C, & Wang Y. Deconvolution of the Human Endothelial Transcriptome. Cell Syst. 3, 218–220 (2016).
Chen H, Orozco LD, Wang J, Rau CD, Rubbi L, Ren S, Wang Y, Pellegrini M, Lusis AJ, & Vondriska TM. DNA Methylation Indicates Susceptibility to Isoproterenol-Induced Cardiac Pathology and Is Associated With Chromatin States. Circ. Res. 118, 786–97 (2016).
Gao C, Ren S, Lee J-H, Qiu J, Chapski DJ, Rau CD, Zhou Y, Abdellatif M, Nakano A, Vondriska TM, Xiao X, Fu X-D, Chen J-N, & Wang Y. RBFox1-mediated RNA splicing regulates cardiac hypertrophy and heart failure. J. Clin. Invest. 126, 195–206 (2016).
Lusis AJ, Seldin M, Allayee H, Bennett BJ, Civelek M, Davis RC, Eskin E, Farber C, Hui ST, Mehrabian M, Norheim F, Pan C, Parks B, Rau C, Smith DJ, Vallim T, Wang Y, & Wang J. The Hybrid Mouse Diversity Panel: A Resource for Systems Genetics Analyses of Metabolic and Cardiovascular Traits. J. Lipid Res. 58, 7250–7 (2016).
Monte E, Rosa-Garrido M, Karbassi E, Chen H, Lopez R, Rau CD, Wang J, Nelson SF, Wu Y, Stefani E, Lusis AJ, Wang Y, Kurdistani SK, Franklin S, & Vondriska TM. Reciprocal Regulation of the Cardiac Epigenome by Chromatin Structural Proteins Hmgb and Ctcf: IMPLICATIONS FOR TRANSCRIPTIONAL REGULATION. J. Biol. Chem. 291, 15428–46 (2016).
Wang JJC, Rau C, Avetisyan R, Ren S, Romay MC, Stolin G, Gong KW, Wang Y, & Lusis AJ. Genetic Dissection of Cardiac Remodeling in an Isoproterenol-Induced Heart Failure Mouse Model. PLoS Genet. 12, 1–30 (2016).
Sun H, Olson KC, Gao C, Prosdocimo DA, Zhou M, Wang Z, Jeyaraj D, Youn J-Y, Ren S, Liu Y, Rau CD, Shah S, Ilkayeva O, Gui W-J, William NS, Wynn RM, Newgard CB, Cai H, Xiao X, Chuang DT, Schulze PC, Lynch C, Jain MK, & Wang Y. Catabolic Defect of Branched-Chain Amino Acids Promotes Heart Failure. Circulation 133, 2038–49 (2016).
Karbassi E, Monte E, Chapski DJ, Lopez R, Rosa Garrido M, Kim J, Wisniewski N, Rau CD, Wang JJ, Weiss JN, Wang Y, Lusis AJ, & Vondriska TM. Relationship of disease-associated gene expression to cardiac phenotype is buffered by genetic diversity and chromatin regulation. Physiol. Genomics 48, 601–15 (2016).
2015
Rau CD, Lusis AJ, & Wang Y. Genetics of common forms of heart failure: challenges and potential solutions. Curr. Opin. Cardiol. 30, 222–7 (2015).
Rau CD, Wang J, Avetisyan R, Romay MC, Martin L, Ren S, Wang Y, & Lusis a. J. Mapping Genetic Contributions to Cardiac Pathology Induced by Beta-Adrenergic Stimulation in Mice. Circ. Cardiovasc. Genet. 8, 40–49 (2015).
Neelankavil J, Rau CD, & Wang Y. The Genetic Basis of Coronary Artery Disease and Atrial Fibrillation: A Search for Disease Mechanisms and Therapeutic Targets. J. Cardiothorac. Vasc. Anesth. 29, 1328–32 (2015).
Rau CD, Parks B, Wang Y, Eskin E, Simecek P, Churchill GA, & Lusis AJ. High-Density Genotypes of Inbred Mouse Strains: Improved Power and Precision of Association Mapping. G3 (Bethesda). 5, 2021–6 (2015).
Parks BW, Sallam T, Mehrabian M, Psychogios N, Hui ST, Norheim F, Castellani LW, Rau CD, Pan C, Phun J, Zhou Z, Yang W-P, Neuhaus I, Gargalovic PS, Kirchgessner TG, Graham M, Lee R, Tontonoz P, Gerszten RE, Hevener AL, & Lusis AJ. Genetic Architecture of Insulin Resistance in the Mouse. Cell Metab. 21, 334–346 (2015).
2013
Parks BW, Nam E, Org E, Kostem E, Norheim F, Hui ST, Pan C, Civelek M, Rau CD, Bennett BJ, Mehrabian M, Ursell LK, He A, Castellani LW, Zinker B, Kirby M, Drake T a, Drevon C a, Knight R, Gargalovic P, Kirchgessner T, Eskin E, & Lusis AJ. Genetic control of obesity and gut microbiota composition in response to high-fat, high-sucrose diet in mice. Cell Metab. 17, 141–152 (2013).
Lagarrigue S, Hormozdiari F, Martin LJ, Lecerf F, Hasin Y, Rau C, Hagopian R, Xiao Y, Yan J, Drake T a, Ghazalpour A, Eskin E, & Lusis AJ. Limited RNA Editing in Exons of Mouse Liver and Adipose Tissue. Genetics 193, 1107–1115 (2013).
Lu G, Ota A, Ren S, Franklin S, Rau CD, Ping P, Lane TF, Zhou ZH, Reue K, Lusis AJ, Vondriska T, & Wang Y. PPM1l encodes an inositol requiring-protein 1 (IRE1) specific phosphatase that regulates the functional outcome of the ER stress response. Mol. Metab. 2, 405–16 (2013).
Rau CD, Wisniewski N, Orozco LD, Bennett B, Weiss J, & Lusis AJ. Maximal information component analysis: a novel non-linear network analysis method. Front. Genet. 4, 28 (2013).
Davis RC, Van Nas A, Bennett B, Orozco L, Pan C, Rau CD, Eskin E, & Lusis AJ. Genome-wide association mapping of blood cell traits in mice. Mamm. Genome 24, 105–18 (2013).
2012
Ghazalpour A, Rau CD, Farber CR, Bennett BJ, Orozco LD, van Nas A, Pan C, Allayee H, Beaven SW, Civelek M, Davis RC, Drake T a, Friedman R a, Furlotte N, Hui ST, Jentsch JD, Kostem E, Kang HM, Kang EY, Joo JW, Korshunov V a, Laughlin RE, Martin LJ, Ohmen JD, Parks BW, Pellegrini M, Reue K, Smith DJ, Tetradis S, Wang J, Wang Y, Weiss JN, Kirchgessner T, Gargalovic PS, Eskin E, Lusis AJ, & Leboeuf RC. Hybrid mouse diversity panel: a panel of inbred mouse strains suitable for analysis of complex genetic traits. Mamm. Genome 23, 680–92 (2012).
Weiss JN, Karma A, MacLellan WR, Deng M, Rau CD, Rees CM, Wang J, Wisniewski N, Eskin E, Horvath S, Qu Z, Wang Y, & Lusis AJ. ‘Good enough solutions’ and the genetics of complex diseases. Circ. Res. 111, 493–504 (2012).
2011
Mungrue IN, Zhao P, Yao Y, Meng H, Rau C, Havel J, Gorgels T, Bergen A, MacLellan WR, Drake T a, Boström KI, & Lusis AJ. Abcc6 deficiency causes increased infarct size and apoptosis in a mouse cardiac ischemia-reperfusion model. Arterioscler. Thromb. Vasc. Biol. 31, 2806–2812 (2011).
2009
Ho MCW, Johnsen H, Goetz SE, Schiller BJ, Bae E, Tran D a, Shur AS, Allen JM, Rau C, Bender W, Fisher WW, Celniker SE, & Drewell R a. Functional evolution of cis-regulatory modules at a homeotic gene in Drosophila. PLoS Genet. 5, e1000709 (2009).